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Research project "Epigenetic regulators & cancer" (ARC program)
Defining the role of key epigenetic regulators during cancer development
This project is focused on Arid1a, Nsd1, Tet2, Mll2 and Mll3, which control different epigenetic mechanisms and are frequently mutated in different cancers. The role and the mechanisms by which mutations in these epigenetic regulators promote tumorigenesis are still unclear. This research will assess the role and the mechanisms by which mutations in these epigenetic regulators promote tumor initiation, progression, metastasis and resistance to therapy in primary mouse cancer models and human patient derived xenotransplantation.
Spokesperson
Cédric Blanpain
Laboratory of Stem Cells and Cancer
Faculté of Medicine
Partner
François Fuks
Laboratory of Cancer Epigenetics
Faculty of Medicine
Dates
Created on September 19, 2018