Defining the role of key epigenetic regulators during cancer development

The genetic landscape of many human cancers demonstrates the high frequency of mutations in epigenetic regulators. The same genes mutated in human cancers are also mutated in some mouse skin cancers, supporting the relevance of this model to study the role of mutations in epigenetic regulators during tumor development.
This project is focused on Arid1a, Nsd1, Tet2, Mll2 and Mll3, which control different epigenetic mechanisms and are frequently mutated in different cancers. The role and the mechanisms by which mutations in these epigenetic regulators promote tumorigenesis are still unclear. This research will assess the role and the mechanisms by which mutations in these epigenetic regulators promote tumor initiation, progression, metastasis and resistance to therapy in primary mouse cancer models and human patient derived xenotransplantation.

Spokesperson

Cédric Blanpain
Laboratory of Stem Cells and Cancer
Faculté of Medicine

Partner

François Fuks
Laboratory of Cancer Epigenetics
Faculty of Medicine

Dates
Created on September 19, 2018