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Research project "Single-cell analysis of bacterial persistence" (ARC program)
This research project will address the question of persistence by using single-cell analysis to understand the molecular mechanisms triggering the differentiation of these elusive persister cells from the vast majority of sensitive cells. Researchers will develop in-house microfluidic chips by 3D laser lithography in order to design trapping chambers of the size of bacteria. Microfluidic chips will then be coupled to fluorescence microscopy, allowing to sort persister cells. Researchers will then proceed to their molecular characterization. Integration of the data will allow them to determine the pathways that are specifically triggered in persister cells.
Spokesperson
Laurence Van Melderen
Cellular and Molecular Microbiology Laboratory
Faculty of Sciences
Partner:
Benoit Scheid
TIPs
Faculty of Applied Sciences
Dates
Created on September 11, 2018