Résonance magnétique nucléaire

Reminders and complements :
  - Basics of solution-state NMR spectroscopy
  - Interpretation of usual one-dimensional (1D) ¹H and ¹³C spectra
  - Interpretation of usual two-dimensional (2D) ¹H and ¹³C spectra

Fourier transform NMR :
  - Instrumentation and sample for solution-state measurements
  - Introduction to the acquisition and processing of 1D NMR spectra
  - Simple sequences with multiple impulsions :
    • Inversion-Recovery – T₁ Filter
    • Spin-Echo, CPMG – T₂ Filtre
    • TOSCY-1D

2D NMR complements

Introduction to the nuclear Overhauser effect (NOE)

Chemical Exchange
  - Lineshape analysis
  - Incoherent longitudinal magnetization transfer experiments

Self-diffusion coefficient measurements

Interpretation of relaxation times

Introduce students to :
  - the principles of Fourier transform NMR spectroscopy, NMR data acquisition and processing;
  - the determination of the molecular structure of (bio)organic compounds via high-resolution 1D and 2D NMR measurements;
  - the thermodynamic and kinetic characterization of chemical equilibria;
  - the characterization of translational and rotational dynamics of molecules.
 

The course consists alternately of theory lessons and practice with correction and discussion of exercises.

References, bibliography, and recommended reading

Claridge T.D.W.; High-Resolution NMR Techniques in Organic Chemistry, 1st ed. 1999 (ISBN 0080427987) or 2nd ed. 2008 (ISBN 0080548180).
Hore P.J.; Nuclear Magnetic Resonance, 1st ed. 1995 (ISBN 0198556829).
Kiemle D.J., Silverstein R.M., Webster F.X.; Identification spectrométrique de composés organiques, 2ème éd. 2007 (ISBN 2804155072).

Course notes

• Université virtuelle

Contacts

Prof. Michel Luhmer
michel.luhmer@ulb.be

Campus

Solbosch, Plaine

Method(s) of evaluation

• Other

Other

A : Open-book written examination (about 3h) - Exercise : determination of the molecular structure of an organic compound and assignment of the NMR signals.
B : Oral examination (about 45 min) : Questions of theory, which can be related to specific experimental observations.

Mark calculation method (including weighting of intermediary marks)

Weighting of about 50% for parts A and B.

Language(s) of evaluation

• french
• (if applicable english )