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Résonance magnétique nucléaire
Course teacher(s)
Michel LUHMER (Coordinator)ECTS credits
5
Language(s) of instruction
french
Course content
Reminders and complements :
- Basics of solution-state NMR spectroscopy
- Interpretation of usual one-dimensional (1D) 1H and 13C spectra
- Interpretation of usual two-dimensional (2D) 1H and 13C spectra
Fourier transform NMR :
- Instrumentation and sample for solution-state measurements
- Introduction to the acquisition and processing of 1D NMR spectra
- Simple sequences with multiple impulsions :
• Inversion-Recovery – T1 Filter
• Spin-Echo, CPMG – T2 Filtre
• TOSCY-1D
2D NMR complements
Introduction to the nuclear Overhauser effect (NOE)
Chemical Exchange
- Lineshape analysis
- Incoherent longitudinal magnetization transfer experiments
Self-diffusion coefficient measurements
Interpretation of relaxation times
Objectives (and/or specific learning outcomes)
Introduce students to :
- the principles of Fourier transform NMR spectroscopy, NMR data acquisition and processing;
- the determination of the molecular structure of (bio)organic compounds via high-resolution 1D and 2D NMR measurements;
- the thermodynamic and kinetic characterization of chemical equilibria;
- the characterization of translational and rotational dynamics of molecules.
Teaching methods and learning activities
The course consists alternately of theory lessons and practice with correction and discussion of exercises.
References, bibliography, and recommended reading
Claridge T.D.W.; High-Resolution NMR Techniques in Organic Chemistry, 1st ed. 1999 (ISBN 0080427987) or 2nd ed. 2008 (ISBN 0080548180).
Hore P.J.; Nuclear Magnetic Resonance, 1st ed. 1995 (ISBN 0198556829).
Kiemle D.J., Silverstein R.M., Webster F.X.; Identification spectrométrique de composés organiques, 2ème éd. 2007 (ISBN 2804155072).
Course notes
- Université virtuelle
Other information
Contacts
Prof. Michel Luhmer
michel.luhmer@ulb.be
Campus
Solbosch, Plaine
Evaluation
Method(s) of evaluation
- Other
Other
A : Open-book written examination (about 3h) - Exercise : determination of the molecular structure of an organic compound and assignment of the NMR signals.
B : Oral examination (about 45 min) : Questions of theory, which can be related to specific experimental observations.
Mark calculation method (including weighting of intermediary marks)
Weighting of about 50% for parts A and B.
Language(s) of evaluation
- french
- (if applicable english )