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Molecular structural characterization and analysis
Course teacher(s)
Gilles BRUYLANTS (Coordinator), Kristin BARTIK and Sebastiaan EELTINKECTS credits
5
Language(s) of instruction
english
Course content
Introduction: Raison d'être of the course
I. Molecules
II. Non Covalent Interactions
III. Importance of Separation Sciences
A. Separation Sciences
A.I. HPLC instrumentation and hyphenation to detectors
A.II. Types of Liquid Chromatography
A.III. Optimization of HPLC separations
A.IV. Band broadening in LC
A.V. Kinetic performance limits
A.VI. Multi-dimensional separations
A.VII. Chip Technology
A.VIII. Gas chromatography
B. Molecular Structure Characterization
B.I. Spectroscopy: general considerations
B.II. Electronic spectroscopies
B.III. Vibrational spectroscopies
B.IV. NMR spectroscopy
Objectives (and/or specific learning outcomes)
The aim of the course is to give you insight into the chromatographic methods available for the isolation and purification of molecules of industrial importance. In addition, we aim to teach you the fundamentals and application possibilities of different spectroscopic methods available for the determination and characterization of molecular structures.
Prerequisites and Corequisites
Required and Corequired knowledge and skills
Basic knowledge in organic chemistry and intermolecular interactions.
Teaching methods and learning activities
Interactive course with powerpoint presentations.
Seminars and practicals illustrate the theory seen during classes.
Contribution to the teaching profile
This teaching unit contributes to the following competences:
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In-depth knowledge and understanding of exact sciences with the specificity of their application to (bio)engineering
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A creative, problem-solving, result-driven and evidence-based attitude, aiming at innovation and applicability in industry and society
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The flexibility and adaptability to work in an international and/or intercultural context
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An integrated insight in (bio)chemical process technology and materials' technology
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Insight in chemistry as a link between process and materials technology
References, bibliography, and recommended reading
Separation Sciences
www.chromacademy.com
HPLC Columns: Theory, Technology, and Practice; U.D. Neue
Wiley-VCH (1997)
Contemporary Instrumental Analysis; K.A. Rubinson and J.F. Rubinson
Prentice-Hall (2000)
Molecular Structure Determination
Introduction to Organic Spectroscopy; L.M. Harwood and T.D.W Claridge
Oxford Chemistry Primers, Oxford Science Publications (1997)
Molecular Spectroscopy; J.M. Brown
Oxford Chemistry Primers, Oxford Science Publications (1998)
Spectrometric Identification of Organic Compounds; R. M. Silverstein, F. X. Webster
John Wiley & Sons Inc (7th edition, 2005 or any other edition)
Understanding NMR Spectroscopy, J. Keeler
Wiley–Blackwell; 2nd Edition (2010)
Course notes
- Podcast
- Université virtuelle
Other information
Contacts
Prof. Gilles Bruylants: gilles.bruylants@ulb.be; Office: P2.2.110 (ULB)
Prof. Sebastiaan Eeltink: Sebastiaan.Eeltink@vub.be (VUB)
Campus
Other campus, Solbosch
Evaluation
Method(s) of evaluation
- written examination
- Group work
written examination
Group work
The exercices and practicals illustrate the content of the courses and are as important as the theory.
Written examination Spectroscopy: students have to elucidate the structure of a molecule on the basis of spectra (IR, UV-Vis, NMR) and to ba able to answer to theoretical questions regarding the conditions to record a quantitative spectrum.
Mark calculation method (including weighting of intermediary marks)
A graded practical will account for 20 % of the final mark. Modalities will be given during class.
A written examination, covering all the material seen during classes and exercise sessions, accounts for the remaining 80% of the final mark.
This grade is the weighted average of two grades, one for each of the teaching units (40% separation science - 60% spectroscopy).
Language(s) of evaluation
- english